#special flags
50.0 500.0 MOLWT
STRIPSALTS yes
#0 10 CHIRALITY
ALLOWED_ATOMS C N O S P Cl F Br I H

# normal format is (min, max, name, SMARTS)

#rules
0 0 Sulfonyl_halides S(=O)(=O)[Cl,Br]
0 0 Acid_halides [S,C](=[O,S])[F,Br,Cl,I]
0 0 Alkyl_halides [Br,Cl,I][CX4;CH,CH2]
0 0 Phosphenes cPc
0 0 Heptanes [CD1][CD2][CD2][CD2][CD2][CD2][CD2]
0 0 Perchlorates OCl(O)(O)(O)
0 7 Fluorines F
0 6 Cl,Br,I [Cl,Br,I]
0 0 Carbazides O=CN=[N+]=[N-]
0 0 Acid_anhydrides C(=O)OC(=O)
0 0 Peroxides OO
0 0 Iso(thio)cyanates N=C=[S,O]
0 0 Thiocyanates SC#N
0 0 Phosphoranes C=P
0 0 P/S_halides [P,S][Cl,Br,F,I]
0 0 Carbodiimides N=C=N
0 0 Cyanohydrines N#CC[OH]
0 0 Carbazides O=CN=[N+]=[N-]
0 0 Sulfate_esters COS(=O)O[C,c]
0 0 Sulfonates COS(=O)(=O)[C,c]
0 0 Pentafluorophenyl_esters C(=O)Oc1c(F)c(F)c(F)c(F)c1(F)
0 0 Paranitrophenyl_esters C(=O)Oc1ccc(N(=O)=O)cc1
0 0 HOBt_esters C(=O)Onnn
0 0 Triflates OS(=O)(=O)C(F)(F)F 
0 0 Lawesson's_reagents P(=S)(S)S
0 0 Phosphoramides NP(=O)(N)N
0 0 Aromatic_azides cN=[N+]=[N-]
0 0 Quaternary_C_Cl_I_P_or_S	[C+,Cl+,I+,P+,S+]
0 0 Beta_carbonyl_quaternary_N C(=O)C[ND4+]
0 0 Acylhydrazides [N;R0][N;R0]C(=O)
0 0 Chloramidines [Cl]C([C&R0])=N
0 0 Isonitriles [N+]#[C-]
0 0 Triacyloximes C(=O)N(C(=O))OC(=O)
0 0 Acyl_cyanides N#CC(=O)
0 0 Sulfonyl_cyanides S(=O)(=O)C#N
0 0 Cyanophosphonates P(OCC)(OCC)(=O)C#N
0 0 Azocyanamides [N;R0]=[N;R0]C#N
0 0 Azoalkanals [N;R0]=[N;R0]CC=O
0 0 (Thio)epoxides,aziridines C1[O,S,N]C1
0 0 Benzylic_quaternary_N cC[ND4+]
0 0 Thioesters C[O,S;R0][C;R0](=S)
0 0 Diand_Triphosphates P(=O)([OH])OP(=O)[OH]
0 0 Aminooxy(oxo) [#7]O[#6,#16]=O
0 0 nitros N(~[OD1])~[OD1]
0 0 Imines C=[N;R0]*
0 0 Acrylonitriles N#CC=C
0 0 Propenals C=CC(=O)[!#7;!#8]
0 0 Quaternary_N [ND4+]
0 0 Constituitively_charged_aromatic_N [nD3+]
0 0 azo [N;D2;$(N=[N;D2]);!$(N(=N)~[#7,#8,#15,#16]);!$(N=N~[#7,#8,#15,#16])]
0 0 Azide N=[N+]=[N-]
0 0 epoxide C1CO1 
0 0 chloroformate C(=O)Cl
0 0 benzylic_halide c[CD2X4][F,Cl,Br,I]
0 0 thioether CSC
0 0 thiol [SD1]
0 0 disulfide S-S
0 0 aldehyde  [CD2](=O)
0 0 N_O_bonds N-O
0 0 N_N_bonds N-N
0 0 michael [$([CH1,CH2]=CC=O)]